Manchester City travel to Anfield on Sunday to face Liverpool in what is quite simply the biggest match of the Premier League season so far.
We’re only in November, but the Reds can take a massive step towards a first top-flight triumph since 1990 if they beat their closest rivals.
Jurgen Klopp’s men have already established a six-point lead over the visitors, who travel without goalkeeper Ederson or influential midfielder David Silva as well as several long term absentees.
Meanwhile, Liverpool have no fresh injury concerns, and the hosts will surely smell blood as they look to continue their unbeaten start to the campaign.
Here, talkSPORT.com takes a look at how both teams could line up for the seismic clash on Merseyside.
How Liverpool could line up
Joel Matip is the only significant absentee for Liverpool, who continue to be without Xherdan Shaqiri and Nathaniel Clyne.
There were doubts surrounding the fitness of Jordan Henderson and Virgil van Dijk, but Klopp revealed both are fit to play.
“Virg was not here [at training on Thursday] for other reasons but he is completely fine,” said Klopp on Friday.
“Jordan is completely fine. Joel is still out, like Shaq (Xherdan Shaqiri) and like Clyney (Nathaniel Clyne). That’s it.”
So the Liverpool starting XI virtually picks itself, as it has done for much of the last year.
The only question facing Klopp will be who partners Van Dijk at centre-back, although Dejan Lovren has forced his way ahead of Joe Gomez in the pecking order.
We also expect Georginio Wijnaldum and Jordan Henderson to get the nod over James Milner and Alex Oxlade-Chamberlain in midfield.
How Man City could line up
For Man City, selection is usually more complicated due to Pep Guardiola’s rotation policy.
However, the changes he makes this week will not be out of choice, with injuries to Ederson and David Silva dealing the City boss a major blow.
However, Guardiola insists using back-up goalkeeper Claudio Bravo isn’t something that worries him, despite his red card in the 1-1 draw at Atalanta on Wednesday.
He said: “He is an exceptional goalkeeper. He is an international goalkeeper. I have no doubts.
“Why shouldn’t I be confident about my players? I see him every day in training. We won’t lose because of Claudio.
“The red card the other day was because we lost the ball. Respect the guy. He is a top keeper.”
Fernandinho has played at centre-back in recent weeks due to the absence of Aymeric Laporte, but we expect Guardiola to be slightly more pragmatic at Anfield.
That would see a more defensively-minded midfield featuring both Ilkay Gundogan and Fernandinho, with John Stones and Nicolas Otamendi in the back four.
Bernardo Silva offers more than Riyad Mahrez off the ball, so it’s likely the Portugual international will start in the front three.
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